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FLASH GENE
Symbol NEXN contributors: mct - updated : 16-12-2009
HGNC name nexilin (F actin binding protein)
HGNC id 29557
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3405 - 675 - 2009 19881492
12 - 3213 - 611 - 2009 19881492
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Skin/Tegumentskinscalp    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminally located actin-binding domains (ABD)
  • one IQ domain
  • one myosin-like globular head domain
  • a coiled-coil domain (CC)
  • a C-terminal immunoglobulin superfamily class
  • HOMOLOGY
    interspecies homolog to murine Nexn
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • F-actin-binding protein at cell-matrix adherens junctions
  • basic FUNCTION
  • may regulate the formations of stress fibers, focal adhesion and its signaling complex, and even participate in the signal transduction in focal adhesions
  • F-actin associated protein that mediates cell motility
  • Z-disk protein, playing an unique role in protecting Z-disks from mechanical trauma
  • crucial protein that functions to protect cardiac Z-discs from forces generated within the sarcomere
  • has a unique role in stabilizing cardiac Z-discs and is essential for maintaining Z-disc integrity against the extreme forces generated during muscle contraction
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • F-actin associated protein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMD1CC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS