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FLASH GENE
Symbol SLC5A1 contributors: mct - updated : 17-01-2019
HGNC name solute carrier family 5 (sodium/glucose cotransporter), member 1
HGNC id 11036
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5061 - 664 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately Homo sapiens
Digestiveintestinesmall intestine  predominantly Homo sapiens
Urinarykidneytubuleconvoluted tubuleproximal tubulepredominantly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiacmyocardium  Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
Muscularmyocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane segments protein (12TM)
  • cytoplasmic N and C termini
  • HOMOLOGY
    interspecies homolog to murine Slc5a1
    Homologene
    FAMILY
  • sodium:solute symporter (SSF) (TC 2.A.21) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in sugar transport across the intestinal brush border
  • major route for the transport of dietary sugars from the lumen of the intestine into enterocytes
  • important glucose transporter in heart
  • contributes to glucose uptake in several tumor cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BRAF enhanced the Na+-coupled glucose transporter SLC5A1 protein abundance in the cell membrane
  • BRAF upregulates SLC5A1 activity, an effect requiring vesicle insertion into the cell membrane
  • STK39 is a powerful negative regulator of SLC5A1 protein abundance in the cell membrane and thus of electrogenic glucose transport
  • role for PER1 in the transcriptional regulation of SLC9A3 and SLC5A1 in the kidney
  • cell & other
    REGULATION
    activated by JAK2 (upregulates SLC5A1 activity which may play a role in the effect of JAK2 during ischemia and malignancy)
    HPV18 E6 oncoprotein that participates in the upregulation of SLC5A1
    BRAF, that upregulates SLC5A1 activity, an effect requiring vesicle insertion into the cell membrane
    Other regulated by luminal monosaccharides
    regulation by AMP-activated protein kinase PRKAB1
    its expression and/or function are regulated by insulin and leptin, and are perturbed in disease
    ASSOCIATED DISORDERS
    corresponding disease(s) GGM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • SLC5A1 and BCL2 expression could serve as prognostic markers in pancreatic cancer
  • Therapy target
    ANIMAL & CELL MODELS