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FLASH GENE
Symbol LMTK3 contributors: mct - updated : 18-11-2014
HGNC name lemur tyrosine kinase 3
HGNC id 19295
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 4972 - 1489 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Nervousbrain   predominantly Homo sapiens
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY LMTK family of protein kinases
CATEGORY
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • tyrosine kinase activity
  • role for LMTK3 in both innate (intrinsic) and acquired (adaptive) endocrine resistance in breast cancer
  • potential role for LMTK3 in promoting integrin activity during breast cancer progression and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a regulator of the estrogen receptor-alpha (ESR1)
  • is involved in the endocytic trafficking of N-methyl-d-aspartate receptors, a type of ionotropic glutamate receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LMTK3 expression was an independent poor prognostic factor in ESR1-positive breast cancer patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    new therapeutic target in breast cancer
    ANIMAL & CELL MODELS
  • Lmtk3(-/-) mice exhibit abnormal behaviors, including pronounced locomotor hyperactivity, reduced anxiety behavior, and decreased depression-like behavior