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FLASH GENE

Symbol

ZKSCAN4

contributors: mlc - updated : 24-11-2007

HGNC name	zinc finger with KRAB and SCAN domains
HGNC id	13854

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 5 - 2307 61.6 545 - Mungall (2003)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Lymphoid/Immune tonsils         Nervous brain       highly Reproductive female system uterus cervix       male system testis       Respiratory lung       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	heart, brain, skeletal muscle, small intestine, and liver tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven C2H2-type zinc fingers
	one KRAB domain
	one SCAN box domain
	an LER domain

HOMOLOGY

Homologene

FAMILY

krüppel C2H2-type zinc-finger protein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing TP53 degradation
	transcriptional repressor that inhibits p53 and p21 transcriptional activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS