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FLASH GENE
Symbol REL contributors: mct/ - updated : 12-09-2017
HGNC name v-rel reticuloendotheliosis viral oncogene homolog (avian)
HGNC id 9954
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2592 - 619 - 2007 18006812
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Respiratoryrespiratory tractlarynx  highly
 respiratory tracttrachea  highly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • IPT/TIG domain with an immunoglobulin like fold
  • RHD domain
  • HOMOLOGY
    interspecies homolog to murine Rel
    intraspecies homolog to avian reticuloendotheliosis viral (v-rel) oncogene
    homolog to NF-kappa B enhancer binding protein,related
    Homologene
    FAMILY
  • NF-kappa B/Rel family of transcription factors
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • participates in the control of a wide array of genes, including genes involved in embryonic development and regulation of immune, inflammation, and stress responses
  • involved in lymphomagenesis (diffuse large B cell lymphoma)
  • may play a role in the pathogenesis of classic Hodgkin lymphoma
  • plays a critical role in regulating the innate inflammatory response to microflora within the lower bowel, likely through its ability to modulate expression of IL12/23 family members
  • necessary for long-term synaptic potentiation and hippocampus-dependent memory formation
  • important for both the thymic development and peripheral homeostatic proliferation of T reg cells
  • with NF-kappaB1 have differential roles in Treg development
  • plays an important role in the expression of IL21 in T cells and subsequently in IL21-dependent T(FH) cell development
  • IKBKB, IKBKG and REL control the levels of Claspin in the cells by an alternative mechanism to cell cycle
  • important function of IKBKB and REL in the DNA-damage response pathway
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the nuclear factor-kappaB (NF-kappaB) transcription factor
  • INTERACTION
    DNA binding to NF-kappa B enhancer
    RNA
    small molecule
    protein
  • interacting with CEBPB (enhances CEBPB binding to the C-reactive protein gene promoter)
  • interact directly with Ca(2+)-loaded calmodulin (can inhibit nuclear import of REL)
  • RBM39 is a new transcriptional coregulator for REL and reveals an important role in modulating REL oncogenic activity
  • REL and JUNB cooperatively regulate FOXP3 expression by modulating the chromatin architecture of FOXP3 promoter region
  • IRF4 activates IL2 and IL4 promoters in cooperation with REL
  • TNFSF13B signals coordinate both RELB and REL activities to ensure survival during peripheral B-cell maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused with BCL11A in B cell lymphoma
    tumoral germinal mutation      
    S525P mutation contributes to the development of B-cell lymphomas by affecting an IKBKA-regulated transactivation activity of REL
    Susceptibility
  • to rheumatoid arthritis
  • to Hodgkin lymphoma
  • Variant & Polymorphism SNP
  • SNPs, rs13031237 and rs13017599 increasing the risk of rheumatoid arthritis
  • SNP increasing the risk of Hodgkin lymphoma
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS