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FLASH GENE
Symbol CXXC5 contributors: shn/mct - updated : 03-03-2020
HGNC name CXXC finger 5
HGNC id 26943
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2601 - 322 - 2019 30971423
3 - 2265 - 322 - 2019 30971423
3 - 2229 - 322 - 2019 30971423
4 - 2695 - 322 - 2019 30971423
4 - 2387 - 322 - 2019 30971423
4 - 2257 - 322 - 2019 30971423
3 - 2163 - 322 - 2019 30971423
3 - 2306 - 322 - 2019 30971423
5 - 2533 - 322 - 2019 30971423
3 - 2215 - 322 - 2019 30971423
4 - 2294 - 322 - 2019 30971423
4 - 2288 - 322 - 2019 30971423
3 - 2200 - 322 - 2019 30971423
4 - 2282 - 322 - 2019 30971423
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouthtongue (see gustatory)   
Lymphoid/Immunethymus    
Nervousbrain    
Reproductivefemale systemovary   
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text in the developing kidney, Wid and Wt1 are coexpressed in podocytes of maturing nephrons.
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal CXXC zinc finger and Dishevelled binding domains (Kim 2010)
  • HOMOLOGY
    interspecies homolog to CXXC4, Homo sapiens
    ortholog to Cxxc5, Mus musculus
    ortholog to Cxxc5, rattus norvegicus
    ortholog to CXXC5, Pan troglodytes
    Homologene
    FAMILY
  • CXXC-type zinc-finger protein family
  • CATEGORY DNA associated , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may participate in activation of the NF- kappa-B and MAPK pathways
  • is a BMP4-regulated modulator of Wnt signaling essential for proper response of telencephalic stem cells to canonical Wnt3a signaling
  • a possible functional role for CXXC5 in forebrain development
  • having regulatory function in both normal and tumoral myelopoiesis (Pendino 2009)
  • physiological function of CXXC5 in nephrogenesis might be conserved in mammals (Kim 2010)
  • plays a crucial role in ATM-p53 signaling in response to DNA damage (Kim 2010)
  • is a negative regulator of the Wnt/CTNNB1 pathway involved in hair regrowth and wound-induced hair follicle neogenesis via an interaction with Dishevelled
  • may act as a tumor suppressor by promoting TGFbeta signaling via a positive feedback loop
  • function of CXXC5 in hepatocellular carcinoma development
  • CXXC5 plays an important role in embryonic development and adult tissue homeostasis by regulating cell proliferation, differentiation and apoptosis
  • important role for CXXC5 as a suppressor of longitudinal bone growth involving growth plate activity
  • is a regulator of the pluripotency network genes and TET enzymes in ESCs
  • CXXC-type zinc finger epigenetic regulator, playing
  • a role in monocyte development
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • CXXC5 forms a complex with NANOG, POU5F1, TET1, and TET2 and facilitates their proper recruitment to regulatory regions of pluripotency and TET genes in ESCs to positively regulate their transcription
  • INTERACTION
    DNA DNA binding
    RNA
    small molecule
    protein
  • Axin2 and Wnt3a
  • physically interacts with ATM and is required for DNA damage-induced ATM phosphorylation but not its recruitment to chromatin (Kim 2010)
  • interacts with Dishevelled via its C-terminal CXXC zinc finger and Dishevelled binding domains and potently inhibits WNT/beta-catenin signaling (Kim 2010)
  • NUDT21 inhibits hepatocellular carcinoma proliferation, metastasis and tumorigenesis, at least in part, by suppressing PSMB2 and CXXC5
  • is able to bind to DNA and act as a transcription factor and epigenetic factor through protein-protein interactions
  • CXXC5 binds to the chromatin and is enriched at promoters and enhancers of TET1, TET2, and pluripotency genes
  • cell & other
    REGULATION
    activated by BONE MORPHOGENETIC PROTEIN 4; BMP4
    WT1 (activates CXXC5 transcription through the upstream enhancer region) (Kim 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyhair 
    CXXC5-Dishevelled interaction is a potential target for the treatment of hair loss
    dermatologyskin 
    potential target for future therapies aimed at improving wound healing
    ANIMAL & CELL MODELS
  • Cxxc5(-/-) mice exhibited accelerated cutaneous wound healing, as well as enhanced keratin 14 and collagen synthesis