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FLASH GENE
Symbol SECISBP2 contributors: mct/npt - updated : 26-02-2009
HGNC name SECIS binding protein 2
HGNC id 30972
RNA
TRANSCRIPTS type messenger
text at least eight splice variants encoding five isoforms with varying N-terminal sequence (Papp 2008)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 3477 - 854 ubiquitous, predominantly in testis Papp (2008)
  • subject to a coordinated transcriptional and translational regulation in response to ultraviolet type A irradiation-induced stress (Papp 2008)
  • 17 - - - - pancreas, thymus, liver, small intestine, brain, corpus callosum, thalamus, testis, t-lymphocyte, fetal brain Papp (2008)
  • having an exon 3b
  • contains a mitochondrial targeting sequence
  • does indeed localize to mitochondria
  • the best represented transcript after the full-length transcript
  • 16 - - - - testis, genito-urinary tumor Papp (2008)
  • lacking exon 3
  • 16 - - - - - Papp (2008)
  • exon 3a
  • 14 - - - - uterus Papp (2008)
    exon 6b, 7b
    15 - - - - squamous cell carcinoma cell lines -
  • exons 6a, 7c
  • 15 - - - - pancreas, retinoblastoma cell lines Papp (2008)
    exons 6a, 7d
    16 - - - - Retinal pigment epithelium, leiomyosarcoma cell lines Papp (2008)
    lack exon 9
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestine   
    Endocrinethyroid   highly
    Reproductivefemale systemuterus   
     male systemtestis  highly
     male systemprostate   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative RNA-binding domain
  • C-terminal domain involved in SECIS binding, ribosome binding and Sec incorporation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • is essential for the cotranslational insertion of sec into selenoproteins
  • may be involved in preventing termination at the UGA/sec codon
  • remains ribosome bound except during selenocysteine delivery to the ribosomal A-site
  • protein of the Sec incorporation machinery, having transcription and translation regulated in a coordinated manner in response to stress (Papp 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • EIF4A3 interaction with the selenoprotein mRNA prevents the binding of SECISBP2, which is required for selenocysteine insertion, thereby inhibiting the synthesis of the selenoprotein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THMD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS