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FLASH GENE

Symbol

BAHD1

contributors: mct/npt - updated : 14-11-2009

HGNC name	bromo adjacent homology domain containing 1
HGNC id	29153

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014952 7 - 4544 NP_055767 - 780 - Bierne (2009)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a C-terminal BAH domain, which is found in several chromatin-binding proteins involved in transcriptional repression and required for BAHD1 colocalization with H3K27me3 (Bierne 2009)

HOMOLOGY

interspecies

homolog to murine AW541238

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	heterochromatinization factor repressing several proliferation and survival genes, in particular the insulin-like growth factor II gene (IGF2)(Bierne 2009)
	acts as a silencer by recruiting at specific promoters a set of proteins that coordinate heterochromatin assembly (Bierne 2009)
	acts as a tumor suppressor through the silencing of cancer-related genes, such as IGF2, in adult tissues (Bierne 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

interacts with HP1, MBD1, HDAC5, and several transcription factors (acts as a silencer that connects heterochromatin factors, such as HP1, MBD1, and HDAC5, to DNA-bound transcription factors, such as SP1, to repress transcription at specific euchromatic loci)(Bierne 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in invasive lung cancer cells (Bierne 2009)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS