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FLASH GENE
Symbol ABLIM3 contributors: mct - updated : 26-09-2022
HGNC name actin binding LIM protein family, member 3
HGNC id 29132
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 4439 - 683 - 2010 20709423
26 - 4340 - 650 - 2010 20709423
25 - 4292 - 634 - 2010 20709423
21 - 4154 - 588 - 2010 20709423
20 - 4106 - 572 - 2010 20709423
26 - 4452 - 683 - 2010 20709423
22 - 4353 - 650 - 2010 20709423
22 - 2864 - 544 - 2010 20709423
20 - 4167 - 588 - 2010 20709423
19 - 4118 - 572 - 2010 20709423
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestiveliver   highly Homo sapiens
Nervousbrainhindbraincerebellum highly Homo sapiens
 spinal cord    
Respiratorylung   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cell lineage
cell lines
fluid/secretion
at STAGE
Text fetal liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four N terminal cysteine-rich LIM/double zinc finger motifs and N-terminal LIM domains of ABLIM3 were sufficient for recruitment to cell-cell contacts
  • a C terminal end homolog to actin-bundling domain of erythrocyte cytoskeleton (dematin like/villin headpiece domain (VHP) domain)
  • HOMOLOGY
    interspecies homolog to rattus LOC307395
    Homologene
    FAMILY actin-binding LIM (abLIM) protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • regulator of cardiomyocyte growth
  • involved in cardiac hypertrophic growth and cardiac muscle-specific gene expression
  • ABLIM3 is likely involved in anchoring LIM domain-binding components of AJs to circumferential actin bundles in specific cell types
  • is a mossy-fiber-terminal-localized cytoskeletal factor whose levels decrease after learning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS