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FLASH GENE
Symbol PVALB contributors: mct - updated : 03-06-2015
HGNC name parvalbumin
HGNC id 9704
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 586 - 110 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex lowly Homo sapiens
Urinarykidneytubuleconvoluted tubuledistal tubulelowly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Pva
homolog to C.elegans F36H12.16
Homologene
FAMILY
  • parvalbumin family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in muscle relaxation
  • its expression levels could influence GABA synthesis
  • skeletal muscle Ca(2+) binding protein, that facilitate myocardial relaxation
  • acts as a unique "delayed" Ca(2+) buffer and facilitates Ca(2+) sequestration from cytosol
  • Ca(2+) buffer and Ca(2+) transporter/shuttle protein that may also play an additional role in Mg(2+) handling
  • cortical GABAergic interneurons expresses PVALB and plays a critical role in the control of pyramidal neuron excitability and the generation of cortical gamma frequency oscillations
  • PVALB-interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus
  • CALB1, CALB2, PVALB, regulate presynaptic inner hair cells (IHCs) function for metabolically efficient sound coding
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for Gitelman's syndrome for SLC12A3-negative cases (Riviera-Munoz 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS