| SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| text
| localized on the plasma membrane and conferred Ca2+-dependent scrambling of phospholipids  |
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localized in the primary cilium of renal epithelial cells |
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is located in late endosomes, where it facilitates the generation of multivesicular bodies for TCR degradation and signal termination |
| basic FUNCTION
| essential component for the Ca2+-dependent exposure of PtdSer (hosphatidylserine) on the cell surface |
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mediates a Ca2+-dependent scramblase activity for PtdSer |
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forms the essential component of ORCC (Outwardly rectifying chloride channels)and seems to have a role for cell shrinkage and programmed cell death |
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is essential for the Ca2+-dependent scramblase activity |
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role in the procoagulant state of platelets during thrombus formation |
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its expression yielded a Ca2+-activated nonselective cation (CAN) channel that is more permeable to Ca2+ than monovalent cations |
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is important, but not sufficient, for the Ca2+-dependent scramblase activity |
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ANO6 is an essential component of a Ca(2+)-activated Cl(-) channel with a Ca(2+) sensitivity that is distinct from that of ANO1/ANO2 and that it is not related to volume-sensitive outwardly rectifying Cl(-) channel (VSOR) activity |
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constitutes a Ca(2+)-activated anion channel or a pore-forming subunit of an anion channel with properties distinct from TMEM16A |
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ANO1 and ANO6 use a similar mechanism for sorting to plasma membrane and protein stabilization, but their functional domains significantly differ |
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plays an essential role in C2C12 myoblast proliferation, likely via regulating the ERK/AKT signaling pathway |
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involved in a variety of functions that include ion transport, phospholipid scrambling, and regulation of other membrane proteins |
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ANO6 proteins are directly involved in dual activity, as a phospholipid scramblase and as an ion channel |
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central role for ANO6 in mediating platelet phosphatidylserine externalization in response to activating and death signals |
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supports volume regulation and volume activation of anion currents by action as a Cl(-) channel or by scrambling membrane phospholipids |
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is a cilium-associated protein, suggesting its functional relevance in cyst formation |
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is an essential component of the microglial response to injury, suggesting the importance of microglial phagocytosis in the pathogenesis of neuropathic pain |
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is the dominant lipid scramblase in T lymphocytes that transports phospholipids across membranes |
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essential for Ca2+-dependent scrambling of membrane phospholipids in platelets, red blood cells, and lymphocytes |
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ANO1 is responsible for basolateral Ca2+-dependent Cl- secretion in RPE, whereas ANO6 and ANO10 may have different functions, such as modulating Ca2+ signals |
