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FLASH GENE
Symbol MESP1 contributors: mct - updated : 02-08-2012
HGNC name mesoderm posterior 1 homolog (mouse)
HGNC id 29658
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1184 28.4 268 - 1996 8787751
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   moderately
Endocrineneuroendocrinepituitary  predominantly
nervousbraindiencephalon   
Reproductivemale systemprostate  highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic helix-loop-helix dimerization domain
  • a unique CPXCP motif
  • a 2-repeat GQ region between the N- and C-terminal domains
  • HOMOLOGY
    interspecies homolog to rattus Mesp1 (67 pc)
    homolog to murine Mesp1 (67.6 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • potentially playing an important role in the development of the nascent mesoderm including primordial germ cells
  • playing a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm
  • definings the rostrocaudal patterning of the somites by participating in distinct Notch pathways
  • cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis
  • has a significant role in the epithelialization of somitic mesoderm
  • a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells
  • involved in cardiovascular differentiation through DKK1-mediated blockade of Wnt-signalling
  • acts as a key regulatory switch during cardiovascular specification, residing at the top of the hierarchy of the gene network responsible for cardiovascular cell-fate determination
  • coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating embryonic stem cells
  • ETS2 and MESP1 play important roles in a genetic network that governs cardiopoiesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text
  • heart involution and morphogenesis
  • mesodermal cell migration
  • PATHWAY
    metabolism
    signaling signal transduction
    notch signaling pathway
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with MESP2 (down-regulated in the later stages of development by the activities of MESP2 in the wild-type embryo)
  • directly binds to regulatory DNA sequences located in the promoter of many key genes in the core cardiac transcriptional machinery, resulting in their rapid upregulation
  • ETS2 plays multifaceted and essential role in cardiogenesis and in combination with MESP1 reprograms human dermal fibroblasts into cardiac progenitors
  • ETS2 plays multifaceted and essential role in cardiogenesis and in combination with MESP1 reprograms human dermal fibroblasts into cardiac progenitors
  • cell & other
    REGULATION
    activated by NOTCH1 (activated NOTCH1 knock-in significantly upregulates MESP1 expression, even in the absence of a Notch signal mediator, PSEN1)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS