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FLASH GENE
Symbol MAPK15 contributors: mct - updated : 28-03-2017
HGNC name mitogen-activated protein kinase 15
HGNC id 24667
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 1904 59 544 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Respiratorylung   highly
 respiratory tractlarynx   
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two SH3-binding motifs in the C-terminal region
  • HOMOLOGY
    intraspecies homolog to ERK7
    Homologene
    FAMILY
  • SER/THR protein kinase family
  • MAP kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as elk-1
  • involved in protein amino acid phosphorylation
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • protein
  • MAP1LC3B, GABARAP and GABARAPL1 are novel interactors of MAPK15, a MAP kinase involved in cell proliferation and transformation
  • cell & other
    REGULATION
    activated by tyrosine and threonine phosphorylation
    an Src-dependent signaling pathway
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS