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FLASH GENE
Symbol AGGF1 contributors: SGE/npt - updated : 09-10-2009
HGNC name angiogenic factor with G patch and FHA domains 1
HGNC id 24684
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4480 - 714 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Epithelialbarrier/liningendothelium  
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one G-patch domain
  • one FHA domain
  • HOMOLOGY
    interspecies homolog to murine Aggf1 (78.7pc)
    homolog to rattus Aggf1 (76.6pc)
    Homologene
    FAMILY
    CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • cytoplasmic in microvascular endothelial cells
  • secreted when endothelial cell tube formation is initiated upon angiogenesis
  • basic FUNCTION
  • acting as a potent angiogenic factor
  • can bind to endothelial cells and promote cell proliferation
  • may act in an autocrine fashion
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • two-component sensor molecule activity
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • interacting with secreted angiogenic factor TNFSF12
  • cell & other
    REGULATION
    induced by GATA1 binding on its activator site (Fan 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s) KTWS1
    Susceptibility Klippel-Trenaunay syndrome (KTS)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS