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FLASH GENE
Symbol HSD17B11 contributors: npt/ - updated : 11-03-2004
HGNC name hydroxysteroid (17-beta) dehydrogenase 11
HGNC id 22960
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1892 33 300 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinepancreas   highly
Reproductivefemale systemovary  highly
 male systemtestis   
Respiratorylung   highly
Skin/Tegumentskin appendagesskin glandsebaceous gland  
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegranulosa cell
ReproductiveLeydig cell
reproductiveovary
cell lineage
cell lines steroidogenic cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SDR motif
  • HOMOLOGY
    interspecies ortholog to murine Dhrs8
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • 17-beta-HSD 3 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • role in androgen metabolism during steroidogenesis, converts 5-alpha-androstane-3-alpha, 17-beta-diol to androsterone
  • oxidoreductase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism hormone
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other down-regulated by cAMP
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS