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FLASH GENE

Symbol

MRPL18

contributors: mct - updated : 17-06-2021

HGNC name	mitochondrial ribosomal protein L18
HGNC id	14477

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014161 4 - 970 NP_054880 - 180 - 2011 21685364 NM_001318817 4 - 821 NP_001305746 - 129 - 2011 21685364

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to E Coli (50S), Drosophila, C Elegans, S Cerevisiae mitochondrial ribosomal protein

Homologene

FAMILY

CATEGORY

structural protein , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,membrane
text	mitochondrial ribosome

basic FUNCTION	mitochondrial proteins biosynthesis
	ribosomal structure and biogenesis
	involved in 5S rRNA import into human mitochondria
	cytosolic MRPL18 incorporates into the 80S ribosome and facilitates ribosome engagement on mRNAs selected for translation during stress

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the large subunit (39S) of the mitochondrial ribosome, including two RNA molecules and, at least, 70 MRPs among which 47 proteins for the large subunit

INTERACTION

DNA

RNA

mRNAs

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function by diabetes both in colonic tumor and mucosa

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS