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FLASH GENE
Symbol SARNP contributors: mct - updated : 03-05-2010
HGNC name SAP domain containing ribonucleoprotein
HGNC id 24432
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 941 23 210 - 2007 17196963
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Cardiovascularheart    
Digestiveliver    
Reproductivemale systemtestis   
Urinarykidney   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain, kidney, liver, heart, thymus, highly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SAF motif and binds to DNA, which led to the speculation that its functions in transcription
  • two NLS
  • three N-glycosylation sites
  • nine potential phosphorylation sites
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Sarnp (96.7pc)
    homolog to murine Sarnp (95.7pc)
    Homologene
    FAMILY
    CATEGORY transcription factor , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • a portion localizes in nuclear speckle domains, and its efficient recruitment to mRNA is both splicing- and cap-dependent
  • basic FUNCTION
  • cytokine regulated protein involved in normal and cancer cell proliferation
  • up-regulated in response to various cytokines
  • may play a role in cell cycle progression
  • enhancing RNA unwinding activity of DDX39
  • may participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis
  • function in splicing, export, or translation, as it binds RNA and interacts with BAT1
  • functions in mRNA export
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SARNP, THOC4, and BAT1 form an ATP-dependent trimeric complex, and BAT1 bridges the interaction between SARNP and THOC4
    INTERACTION
    DNA
  • specifically binding to scafflod/matrix attachement region DNA
  • binding both double-stranded and ss DNA
  • RNA binding to ssRNA
    small molecule
    protein
  • interacting with FUS
  • binding BAT1 and DDX39
  • with THOC4, associate with TREX in an ATP-dependent manner, and BAT1 mediates the association between these proteins and the THO complex to form TREX
  • cell & other
    REGULATION
    induced by erythropoietin
    Other up-regulated by EPO and THPO, FLT3LG, KITLG
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma and pancreatic adenocarcinoma
    tumoral   translocation   protein chimeric
    t(11;12)(q23;q13) in an infant with AML-M4 resulting in a fusion protein
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS