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FLASH GENE
Symbol SPAG16 contributors: mct/npt - updated : 25-05-2020
HGNC name sperm associated antigen 16
HGNC id 23225
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2189 71 631 - 2011 21655194
  • SPAG16L
  • meiotically expressed 71-kDa protein is incorporated into the central apparatus (Zhang 2004)
  • essential for sperm flagellar function (Zhang 2006)
  • SPAG16L promoters reveals the existence of multiple putative SOX5 binding sites
  • 5 - 1296 35 183 . nuclear, testis-specific . expressed only in male germ cells, and is predominantly found in specific regions within the nucleus 2011 21655194
  • represents the C-terminus (exons 11-16) of SPAG16L
  • SPAG16S
  • bind to meiosis expressed gene 1 product (MEIG1), a protein originally thought to play a role in meiosis
  • 35-kDa protein, which accumulates in postmeiotic male germ cells, is abundant in the nucleus
  • plays an important role in the gene expression machinery of male germ cells
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
     nervespinal nervesciatic highly
     spinal cord   highly Homo sapiens
    Reproductivefemale systemovary    Homo sapiens
     male systemtestis  highly Mus musculus
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Reproductivesperm cell Mus musculus
    Reproductivespermatocyte Mus musculus
    Respiratoryalveolar cell type II
    Respiratoryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal WD repeats
  • HOMOLOGY
    interspecies ortholog to Chlamydomonas Pf20
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text localized to the tails of permeabilized sperm, in the axoneme central apparatus
    basic FUNCTION
  • bi-functional gene essential for spermatogenesis (Zhang 2009)
  • essential component of the axoneme central apparatus, that has multiple functions during spermatogenesis (Zhang 2004)
  • potential role of SPAG6 and SPAG16 stabilizing the cytoplasmic microtubules of eukaryotic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TSSK2 associates with SPAG16 via its C-terminal domain bearing WD repeats
  • RCBTB2 is a binding partner of sperm associated antigen 16S (SPAG16S), which is a regulator of spermiogenesis
  • MEIG1/PACRG forms a complex in the manchette and this complex is necessary to transport cargos, such as SPAG16, to build the sperm flagella
  • S-SOX5 directly interacts with the SPAG16L promoter
  • TCEB2 is a major binding partner of sperm-associated antigen 16S (SPAG16S), a component of nuclear speckles
  • as a major binding partner of SPAG16S, TCEB2 may play an important role in spermatogenesis by modulating RNA maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS