basic FUNCTION
| involved in spermatogenesis and may be a target gene mediating the reproductive toxicity induced by TCDD |
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may be associating with transcriptionally active nuclear subregions in interphase cells and concentrating at the ends of formed chromosomes during mitosis |
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is required to unlock cohesin from a particular state in which it is stably bound to chromatin |
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promoting sister-chromatid resolution in mitotic prophase |
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playing an important role in tumorigenesis and cell cycle progression |
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contributing to tumor progression by induction of chromosomal instability (CIN) |
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essential for the prophase removal of sister chromatid arm cohesins |
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WAPL protein regulates binding of the cohesin complex to chromosomes during interphase and helps remove cohesin from chromosomes at mitosis |
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is a key negative regulator of cohesin and forms a complex with precocious dissociation of sisters protein 5 (PDS5A, PDS5B) to promote cohesin release from chromatin |
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in mitosis, WAPL-mediated release of cohesin from DNA is essential for proper chromosome segregation and protects cohesin from cleavage by the protease separase |
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WAPL-dependent prophase pathway is essential for proper chromosome segregation and is crucial to maintain genomic integrity |
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cohesin dynamics are controlled by the releasing factors PDS5B and WAPL and the cohesin stabilizer CDCA5 |
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plays a critical role in silencing of Polycomb group (PcG) target genes through the interaction of distal cis-regulatory element (CRE) with promoters |
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cohesin regulator WAPL promotes the release of cohesin from chromosomes during both interphase and mitosis |
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NEK1 phosphorylates PPP1CC, leading to the dephosphorylation of WAPL, which, in turn, results in its retention on chromosome cores to promote loss of cohesion at the end of prophase I in mammals |
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balanced activity of NIPBL/MAU2 and WAPL enables cohesin to correctly structure chromosomes |