basic FUNCTION
| increasing the catalytic rate of RNA polymerase II transcription elongation by suppressing transient pausing by the polymerase at multiple sites along the DNA |
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promotes the differentiation of ESCs by activating the expression of EMT-related genes and by suppressing TP53 expression |
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unique role for ELL3 at enhancers for the priming of gene activation during stem cell specification |
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could prime gene activation by marking enhancers as early as in the germ cells |
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enhancer-associated ELL3 is essential for stem cell specification |
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might potentially serve as an epigenetic marker in germ cells by bookmarking the inactive enhancers of genes for future activation in the embryo |
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RNA polymerase II transcription elongation factor that is enriched in testis |
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may play a critical role in promoting oncogenesis in breast cancer by regulating cell proliferation and cancer stem cell properties via the ERK1/2 signaling pathway |