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FLASH GENE
Symbol GSTO2 contributors: mct - updated : 09-12-2014
HGNC name glutathione S-transferase omega 2
HGNC id 23064
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1546 - 243 - 2005 15942673
6 - 1444 - 209 - 2005 15942673
6 - 981 - 215 - 2005 15942673
4 - 879 - 181 - 2005 15942673
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 liver    
Endocrinepancreas   highly
 parathyroid   highly
Reproductivemale systemprostate   
 male systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • thioredoxin-like domains
  • a glutathione binding site where glutathione can form a disulfide bond with a conserved active site cysteine residue positioned near the N-terminal end of helix 1
  • HOMOLOGY
    intraspecies homolog to GSTO1
    Homologene
    FAMILY GST superfamily, omega family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • having glutathione transferase activity
  • may play an important role in cellular signaling
  • two isozymes (GSTO1 and GSTO2) have significant DHA reductase (DHAR) activity
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to ovarian cancer
  • to late onset Alzheimer disease (Webster 2009)
  • Variant & Polymorphism other polymorphism associated with the risk of ovarian cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS