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FLASH GENE
Symbol NLRP8 contributors: mct - updated : 01-12-2020
HGNC name NLR family, pyrin domain containing 8
HGNC id 22940
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3934 - 1048 - 2008 18648497
10 - 3877 - 1029 - 2008 18648497
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary    Homo sapiens
 male systemtestis    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DAPIN domain
  • a NACHT domain
  • a leucine-rich repeat (LRR) region
  • HOMOLOGY
    Homologene
    FAMILY NALP family, caterpiller family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cells response to microbial infection (Tschopp 2003)
  • play important roles in both mammalian innate immune system and reproductive system (Tian 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to lung cancer
    Variant & Polymorphism other rs402969, NLRP8, C > T, were identified as novel lung cancer susceptibility variants
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS