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FLASH GENE
Symbol TOMM7 contributors: mct/npt - updated : 14-06-2008
HGNC name translocase of outer mitochondrial membrane 7 homolog (yeast)
HGNC id 21648
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 746 6.2 55 - Johnston (2002)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineadrenal gland    
 thyroid   highly
Lymphoid/Immunetonsils   highly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNAPK phosphorylation site
  • two N-myristoylation motifs
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
  • Tom7 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in intracellular protein transport
  • may play a role in destabilizing the interactions between the TOM complex and the TOM receptor
  • required for stabilization of the TOM complex
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport , mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
  • small regulatory component of the translocase of the outer mitochondrial membrane
  • C9orf105 as well as TOMM7, were associated with TOMM40 in the TOM complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexed with TOM40 and TOM22
  • cell & other
    REGULATION
    Other levels of TOM22 in mitochondria can accelerate the rate of TOMM7 assembly into the mature TOM complex
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS