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FLASH GENE
Symbol NCOA7 contributors: mct/pgu - updated : 07-08-2008
HGNC name nuclear receptor coactivator 7
HGNC id 21081
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 splicing 5455 106 942 - 2002 11971969
16 splicing 5422 104.8 931 - 2002 11971969
  • using an alternate in-frame splice site compared to variant 1
  • - - - - - restricted to the reproductive system organs, particularly the uterus and the ovary 2008 18299425
  • unlike NCOA7, possesses a unique and highly conserved exon at the 5prime end and encodes a protein with a unique N-terminal sequence
  • one identifiable domain, TLDc, which has recently been suggested to be involved in protection from oxidative DNA damage
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrainlimbic systemhippocampus predominantly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectiveadipose  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a LysM repeat
  • a TLD domain
  • HOMOLOGY
    interspecies homolog to murine Ncoa7 (83 pc)
    intraspecies paralog to OXR1
    Homologene
    FAMILY
  • OXR1 family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a coactivator of endogenous ER alpha target genes by binding to the promoter region after its recruitment by estrogen-bound ER alpha
  • enhancing the transcriptional activities of several nuclear receptors
  • involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA
  • like its homologue, OXR1, NCOA7 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance
  • plays an important role in the regulation of ATRA-mediated neuronal differentiation, and is a novel member of prognostic indicators for neuroblastoma
  • OXR1 and its close homolog NCOA7 are produced in many different forms either as a result of alternative splicing, or alternative transcription start sites
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ER alpha
  • interacting with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner
  • interacting with the heterodimer AHR- ARNT
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS