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FLASH GENE
Symbol MBD5 contributors: /mct - updated : 24-11-2021
HGNC name methyl-CpG binding domain protein 5
HGNC id 20444
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 9512 159.8 1494 - 2021 33427406
14 - 10732 - 1727 - 2021 33427406
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   lowly
Endocrinepancreas   highly
Nervousbrain   highly Homo sapiensAdult
Respiratorylung   lowly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • CpG binding domain
  • a PWWP domain
  • a putative Methyl-Binding Domain (MBD)
  • HOMOLOGY
    interspecies homolog to rattus LOC311026
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text colocalize with heterochromatin (Laget 2010)
    basic FUNCTION
  • may be a transcription coactivator
  • may contribute to the formation or function of heterochromatin (Laget 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with KIAA1549
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q23 , MRD1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    ID via EHMT1-associated chromatin modification module
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS