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FLASH GENE
Symbol G2E3 contributors: mct/npt - updated : 17/09/2008
HGNC name KIAA1333
HGNC id 20338
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5581 80.5 706 - Brooks (2008)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta, early stages of limb bud formation of the developing embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nucleolar localization signal (NoLS) in its N-terminus
  • a transcription factor TCF20 domain
  • a RING domain and an atypical domain with similarities to both RING variant and PHD domains
  • a conserved HECT domain within the C-terminus indicated that it likely functions as a ubiquitin ligase or E3
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text shuttles between the cytoplasm and nucleus, concentrating in nucleoli and relocalizing to the nucleoplasm in response to DNA damage
    basic FUNCTION
  • having ubiquitin-protein ligase activity
  • nucleo-cytoplasmic shuttling protein with nuclear export mediated by a novel nuclear export domain that functions independently of XPO1
  • having a possible role in cell cycle regulation and the cellular response to DNA damage
  • having dual function ubiquitin ligase essential for prevention of apoptosis in early embryogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS