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FLASH GENE
Symbol RRAGB contributors: mct - updated : 11-10-2016
HGNC name Ras-related GTP binding B
HGNC id 19901
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing 2133 - 346 - 1995 7499430
RAGBs
11 splicing 2217 43 374 brain 1995 7499430
  • insertion of 28 codons between PM2 and PM3
  • RAGBl
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Lymphoid/Immunespleen    
     thymus    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine LOC245670
    homolog to rattus Ragb
    Homologene
    FAMILY Ras family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,nucleus
    basic FUNCTION
  • GTPase activity
  • do not directly stimulate the kinase activity of MTOR, but, like amino acids, promote the intracellular localization of MTOR to a compartment that also contains its activator RHEB
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • bind raptor and mediate amino acid signaling to MTOR
  • a complex encoded by the LAMTOR1, LAMTOR2, LAMTOR3 genes, which we term Ragulator, interacts with the RRAGA, RRAGB, RRAGC, RRAGD, recruits them to lysosomes, and is essential for MTOR activation
  • recently identifed as a negative regulator of Rag GTPases (RRAGA, RRAGB, RRAGC, RRAGD)
  • WDR35 is associated with RRAGA, RRAGB, RRAGC and might negatively influence MTOR activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS