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FLASH GENE
Symbol KCNG4 contributors: - updated : 13-04-2004
HGNC name potassium voltage-gated channel, subfamily G, member 4
HGNC id 19697
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1681 58 519 - Ottschytsch et al. (02)
encodes the longest isoform
- splicing 2233 - 256 - Ottschytsch et al. (02)
variant 2 has an alternate 3' sequence resulting in an isoform 2 shorter and distinct in the C terminus
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  lowly
 intestinelarge intestinecolon lowly
 liver   lowly
Nervousbrain   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
K+ channel tetramerisation domain
mono polymer heteromer , tetramer
HOMOLOGY
Homologene
FAMILY K+ channel family, G subfamily
CATEGORY regulatory , transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
text remains intracellular in the absence of KCNB1
basic FUNCTION
  • modulates channel activity by shifting the treshold and the half-maximal activation to more negative values
  • controls the excitability of electrically active cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein heteromultimerizing with KCNB1, KCNC1 and KCNF1 to form the K+ channel
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS