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FLASH GENE
Symbol DIRAS2 contributors: - updated : 12-03-2004
HGNC name DIRAS family, GTP-binding RAS-like 2
HGNC id 19323
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral lobefrontalhighly
 brainhindbraincerebellumcerebellar cortexhighly
 brainforebraincerebral lobeoccipitalhighly
 brainhindbraincerebellum highly
 brainforebraincerebral lobetemporalhighly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
GTP-binding domain, an effector domain and a C terminal prenylation motif
HOMOLOGY
interspecies homolog to C.elegans C54A12.4
homolog to D.melanogaster CG8500
intraspecies homolog to DIRAS1
homolog to ARHI
Homologene
FAMILY Ras subfamily of Ras small GTPases
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • low level of GTPase activity
  • might regulate cell morphogenesis in a manner distinct from other Ras proteins
  • might function as a growth suppressor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    DIRAS2 exists predominantly as a GTP-bound form
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS