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FLASH GENE
Symbol KLHL10 contributors: mct - updated : 24-08-2022
HGNC name kelch-like 10 (Drosophila)
HGNC id 18829
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2163 - 608 - 2006 17047026
5 - 2012 - 608 - 2006 17047026
5 - 1950 - 520 - 2006 17047026
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one BTP/POZ domain and six Kelch repeats
HOMOLOGY
interspecies homolog to murine Klhl10
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • may be involved in regulatory/signal transduction mechanisms
  • plays an important role in male fertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein binding
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF11
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deletion or mutation of the Klhl10 gene in Drosophila or mice results in defects in spermatogenesis or sperm maturation