Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TMEM47 contributors: mct - updated : 15-09-2012
HGNC name transmembrane protein 47
HGNC id
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 4068 20 181 - 2001 11472633
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine   
 liver    
Lymphoid/Immunespleen    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidneynephronrenal capsuleglomeruluslowly Homo sapiens
 kidneytubuleconvoluted tubule lowly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Urinarypodocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, perinatal
Text
  • expression of TM4SF10 peaked at postnatal day 4 and was virtually absent in adult kidneys
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four putative transmembrane domains
  • HOMOLOGY
    interspecies ortholog to C- elegans VAB-9
    Homologene
    FAMILY
  • PMP22/EMP/claudin protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • localizes at the basal-most region of podocyte precursors before the capillary loop stage, at some tubule precursors, and at the ureteric bud junction with S-shaped bodies
  • localized to the perinuclear region and translocated to the cell membrane after Cadherin appearance at cell-cell contacts
  • basic FUNCTION
  • functions during differentiation of podocytes and may participate in the maturation of cell junctions from simple adherens junctions to elaborate slit diaphragms
  • claudin-like proteins that function during junctional development
  • claudin-like cell junction protein that is transiently expressed during podocyte development where its expression is downregulated in differentiating podocytes coincident with the appearance of nephrin at the slit diaphragm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting witrh FYN (may have a regulatory role in suppressing FYN activity)
  • interaction with FYB, a FYN adapter protein expressed in podocytes, and TMEM47 possibly through FYB, may regulate FYN activity
  • cell & other
    REGULATION
    Other its expression is temporally regulated during kidney development
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS