basic FUNCTION
| ribosomal protein S6 kinase, serine/threonine kinase, non receptor type, not involved in vivo in the phosphorylation of RPS6, mediating protein synthesis initiation and elongation induced by hormones or growth factors |
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may be playing an essentilal regulatory role in protein synthesis during cell proliferation |
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modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of NFKBIB |
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associates with and phosphorylates NOS1 on Ser847 following mitogen stimulation, suggesting a novel role for RPS6KA1 in the regulation of nitric oxide function in brain |
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ERK-RPS6KA1 activation by growth factors delays G2/M transition and this might be required to maintain genomic integrity during growth factor stimulation |
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facilitates nuclear CHEK1 accumulation through CHEK1-Ser-280 phosphorylation and this pathway plays an important role in the preparation for monitoring genetic stability during cell proliferation |
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major downstream effector of the kinase mammalian target of rapamycin, in leucine deprivation stimulation of energy expenditure |