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FLASH GENE
Symbol ELP2 contributors: mct - updated : 28-02-2017
HGNC name elongation protein 2 homolog (S. cerevisiae)
HGNC id 18248
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 2652 92 826 - 2002 11818576
23 - 2847 - 891 - 2002 11818576
21 - 2637 - 821 - 2002 11818576
21 - 2574 - 800 - 2002 11818576
19 - 2441 - 756 - 2002 11818576
20 - 2442 - 756 - 2002 11818576
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve WD repeats
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to rattus Statip1
    Homologene
    FAMILY
  • WD repeat ELP2 family
  • CATEGORY adaptor , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulates the ligand-dependent activation of STAT3
  • may have a role in chromatin structure and transcription via the elongator complex and its histone actelytransferase activity
  • is a necessary component for functional Elongator and acts as a hub in the formation of various complexes
  • ELP1, ELP2, ELP3, ELP4, ELP5, ELP6 plays vital roles in gene regulation
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • subunit of the elongator complex (ELP3, IKAP, ELP4, STATIP1)
  • core Elongator complex formed by IKBKAP, ELP2, and ELP3 was rather stable, whereas ELP4, ELP5, and ELP6 might loosely contact and work together with the core Elongator to regulate cell functions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with preferentially unphosphorylated STAT3
  • affinity for member of the Jak family proteins
  • cell & other
  • binds microtubules through its conserved alkaline residues
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRT58
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    targeting ELP2 activity is a novel therapeutic option to limit the inhibition of osteoblast differentiation by inflammatory microenvironment
    ANIMAL & CELL MODELS