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FLASH GENE

Symbol

SPATA5

contributors: mct - updated : 12-10-2015

HGNC name	spermatogenesis associated 5
HGNC id	18119

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_145207 16 - 8152 NP_660208 - 893 - 2015 26299366

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Homo sapiens Lymphoid/Immune spleen         Homo sapiens Nervous brain forebrain cerebral cortex     Homo sapiens   brain limbic system hippocampus     Homo sapiens Reproductive male system testis       Mus musculus   male system testis       Homo sapiens Skin/Tegument skin         Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	highly conserved ATPase domain, which is involved in a variety of cellular processes, including protein unfolding and degradation, microtubule motor movement, DNA replication, and membrane fusion
	a putative mitochondrial targeting sequence and two AAA domains

HOMOLOGY

interspecies	homolog to murine Spata5
	homolog to rattus LOC361935

Homologene

FAMILY

AAA ATPase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION	involved in spermatogenesis
	might be involved in regulating the structural integrity of mitochondria during spermatogenesis
	might play a role in post-translational modification during cell differentiation in neuronal development

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

TWIST1-binding sequences associated with CHST11, LITAF, ROR2, and SPATA5 also bound the potential TWIST1 cofactor RREB1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

EHLMRS

Susceptibility

to Alopecia areata (AA)

Variant & Polymorphism SNP	SNP in an intronic region of the SPATA5 associated to susceptibility for AA

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS