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FLASH GENE
Symbol NAGPA contributors: - updated : 11-04-2007
HGNC name N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
HGNC id 17378
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver    
Lymphoid/Immunetonsils   highly
Nervousbrain    
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal signal sequence
  • a transmembrane region
  • six N-glycosylation potential sites
  • mono polymer homomer , tetramer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • removes a covering N-acetylglucosamine from the mannose-6-phosphate recognition marker on lysosomal acid hydrolases
  • can hydrolyses UDP-GlcNAc
  • involved in trafficking pathway and playing a crucial role in the process of lysosomal biogenesis
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    trafficking pathway
    a component homotetramer of two disulfide-linked homodimers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by cleavage via the furin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS