Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | AFF3 | contributors: mct/npt - updated : 26-05-2021 |
HGNC name | AF4/FMR2 family, member 3 |
HGNC id | 6473 |
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RNA |
TRANSCRIPTS | type | messenger |
---|
text | multiple alternatively spliced transcript variants that encode different proteins have been found for this gene |
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EXPRESSION |
Type | widely |
tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to murine Laf4 |
intraspecies | homolog to MLLT2 ( AF4) and FMR2 (nut2), highly |
Homologene |
FAMILY |
CATEGORY | transcription factor , protooncogene |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,nucleus,nucleoplasm,nuclear bodies | |
text |
basic FUNCTION | |
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CELLULAR PROCESS | nucleotide, transcription, regulation |
PHYSIOLOGICAL PROCESS | development |
text | oncogenesis |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA | binding |
RNA |
small molecule |
protein | |
| |
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cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | KINSSHIP |
Other morbid association(s) |
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Susceptibility | to rheumatoid arthritis (RA) |
Variant & Polymorphism other | association of the AFF3 locus with RA susceptibility (Barton 2009) |
Candidate gene | for specific changes of the tibia | |
Marker
Therapy target
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ANIMAL & CELL MODELS |