basic FUNCTION
| transcription factor, gamma regulating the expression of genes required for development of ectodermal tissues |
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playing a role in the development of the eyes, face, body wall, limbs, and neural tube |
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controls hormone response in breast cancer cells through multiple pathways of estrogen signaling |
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with TFAP2A, play an essential role in tumorigenesis |
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its activity at specific target genes depends upon epigenetic chromatin structure, and interaction with ESR1 promoter is controlled by chromatin structure |
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important role for TFAP2C, SMARCA4, and EOMES in trophoblast stem cell self-renewal |
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may play a role in the estrogen signaling pathway |
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transcription factor involved in mammary development, differentiation, and oncogenesis |
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plays a critical role in gene regulation in hormone responsive breast cancer |
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potentially cooperate with CDX2 to override the pluripotency program and establish the extraembryonic trophoblast maintenance program |
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inducing CDX2 and repressing NANOG expression (suggests that the maintenance of trophoblast stem cell fate requires both TCFAP2C and CDX2 protein function |
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plays a critical role in gene regulation in hormone responsive breast cancer and its target genes are different than for the ERBB2 breast cancer phenotype |
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established role of GPX1 in breast cancer, providing an important mechanism for TFAP2C to further influence oncogenesis and progression of breast carcinoma cells |
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influences development of the luminal cell type during mammary development, suggesting that TFAP2C has an important role in regulated luminal-specific gene |
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facilitates trophectoderm lineage specification by functioning as a key regulator of CDX2 transcription, cell polarity and position-dependent HIPPO signaling |
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required for placental development and trophoblast stem cell maintenance |
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