Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARID4B contributors: mct - updated : 21-08-2010
HGNC name AT rich interactive domain 4B (RBP1- like)
HGNC id 15550
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 6067 147.8 1312 - Fleischer (2003)
23 - 5809 137.6 1226 - Fleischer (2003)
lacking exon 18, leading to a shorter isoform missing an internal segment compared to isoform 1
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   lowly
Reproductivefemale systemovary  lowly
 male systemtestis  highly
 male systemprostate  lowly
cell lineage
cell lines highly expressed in breast, lung, colon, pancreatic, ovarian carcinomas
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Tudor domain
  • a ARID/BRIGHT DNA binding domain
  • two RRM (rna recognition motif) domains
  • HOMOLOGY
    interspecies ortholog to rattus arid4b
    ortholog to murine Arid4b
    Homologene
    FAMILY
  • RBM334 family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • antigenic epitope (IKPSLGSKK) recognized by IgG antibodies
  • may be a molecular marker associated with a broad range of human malignancies
  • member of epigenetic complexes regulating genomic imprinting at the PWS/AS domain (Wu 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the mSin3A corepressor complex
  • INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    heterozygous deficiency for Rbbp1l1/Arid4b altered epigenetic modifications at the Prader-Willi syndrome -IC with reduced trimethylation of histone H4K20 and H3K9 and reduced DNA methylation, changing the maternal allele toward a more paternal epigenotype (Wu 2006)