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FLASH GENE
Symbol MUC15 contributors: - updated : 15-04-2004
HGNC name mucin 15
HGNC id 14956
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
 intestinelarge intestine   
Hearing/Equilibriumearinnercochlea  
Lymphoid/Immunetonsils    
Reproductivefemale systembreast   
 female systembreastmammary gland  
 female systemovary   
 male systemprostate   
 male systemtestis   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Respiratoryepithelial cell
cell lineage
cell lines
fluid/secretion milk
at STAGE
physiological period fetal, pregnancy
Text placenta, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal peptide signal
  • an extracellular N-terminal region rich in ser, thr, pro, leu, and asn residues
  • a transmembrane domain
  • containing numerous potential glycosylation sites (O and N types)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to bovine Muc15
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides
  • provides a physical barrier protecting the underlying epithelium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS