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FLASH GENE
Symbol PPP1R2 contributors: mct - updated : 21-09-2012
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 2
HGNC id 9288
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3475 - 205 - 2008 19036150
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Reproductivefemale systembreastmammary gland highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Ppp1r2
homolog to C.elegans Y32H12A.4
intraspecies homolog to IPP-2
Homologene
FAMILY protein phosphatase inhibitor 2 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
text
  • found concentrated in cilia of epithelial cells, and was localized to cilia early in the process of formation, prior to the full acetylation of microtubules
  • basic FUNCTION
  • inhibitor subunit of protein phosphatase 1, involved in mammalian cell division
  • acts to enhance Aurora B by inhibiting specific PPP1CA holoenzymes that dephosphorylate Aurora B substrates necessary for chromosome segregation and cytokinesis
  • localizes to the primary cilium where it affects both Ser/Thr phosphorylation and is required for full tubulin acetylation
  • as a multifunctional protein, may link cell cycle progression to structure and stability of the primary cilium
  • major serine/threonine-phosphatase whose activity is dependent on its binding to regulatory subunits known as PP1 interacting proteins (PIPs), responsible for targeting PP1 to a specific cellular location, specifying its substrate or regulating its action
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    energy pathways
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein catalytic subunit of PP1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal, lung, gastric ovarian carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS