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FLASH GENE
Symbol CCR5 contributors: mct - updated : 07-07-2010
HGNC name chemokine (C-C motif) receptor 5
HGNC id 1606
RNA
TRANSCRIPTS type messenger
text differing in their 5'utr by alternative splicing of exon 2 and exon 3
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 initiation site 3686 40.5 352 lymphocytes - 8663314
3 initiation site 3451 62 352 - - 8663314
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 thymus    
Urinarykidney    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines promyeloblastic cell line
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five transmembrane domains (TM3-TM6) sufficient for the function
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • mediating macrophage-tropic strains of HIV-1 entry in CD4+ T lymphocytes
  • during human T cell activation by antigen-presenting cells, recruited into the immunological synapse, where they deliver costimulatory signals
  • important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction
  • CXCR4 and the related CCR5 serve as co-receptors for HIV-1 viral particles, facilitating their entry into cells
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS immunity/defense
    text granulocyte
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
  • DARC hetero-oligomerizes with the CC chemokine receptor CCR5 (DARC-CCR5 interaction impairs chemotaxis and calcium flux through CCR5)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PRAF2
  • interaction between CXCR4 and CCR5 to exert specific biological functions and modulate T lymphocyte responses, and cooperation between receptors represents one key strategy for the functional plasticity of chemokines
  • interacting with TPST2 (involved in tyrosine sulfation of CCR5 N-terminal peptide)
  • interacting with arrestins (arrestins may serve as scaffolding proteins linking CCR5 to multiple downstream signaling molecules in a biologically important primary cell type)
  • cell & other
    REGULATION
    activated by IL-10 (associated with increased migration of microglia in response to macrophage inflammatory protein-1 beta)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to AIDS lymphoma
  • to HIV disease progression, resistance or non progressive infections
  • to West Nile virus (Omim 610379)
  • to juvenile idiopathic arthritis (JIA)
  • Variant & Polymorphism other
  • reduced risk of AIDS lymphoma with the CCR5-delta 32 mutation
  • CCR5Delta32 is a functional variant, significantly associated with protection from developing JIA
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS