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FLASH GENE
Symbol TM9SF2 contributors: mct/npt - updated : 25-02-2009
HGNC name transmembrane 9 superfamily member 2
HGNC id 11865
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 2391 75.64 663 - Schimmoller (1998), Dunham (2004)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveliver    
Endocrinepancreas   highly
Nervousbrain   lowly
Reproductivefemale systemplacenta  lowly
Respiratorylung    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines Jurkatt T-cells
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N-terminal extracellular domain
  • nine putative transmembrane domains (Bergeret 2008)
  • HOMOLOGY
    interspecies homolog to murine Tm9sf2
    homolog to rattus LOC306197
    Homologene
    FAMILY
  • nonaspanin (TM9SF2) family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text type I transmembrane protein
    basic FUNCTION
  • transporter activity
  • required with TM9SF4 for bacterial internalisation in S2 cells, where they displayed partial redundancy (Bergeret 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with RAB9
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS