basic FUNCTION
| protein kinase activity |
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involved in chromosome condensation and segregation |
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promotes cell migration through the activation of AKT1 |
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mediator of pancreatic ductal cell migration and invasion |
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is a polyubiquitin binder |
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negatively regulates NF-kappaB signaling pathway activated by TNFalpha dependent on its kinase activity and NF-kappaB signaling pathway activated by caspase-10 independent of its kinase activity |
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cytoplasmic protein that does not seem to shuttle between nucleus and cytoplasm via a XPO1-dependent mechanism |
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is potentially a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells, required for normal processing of the 21S pre-rRNA |
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fFunctionally, RIOK3 acts as a SUFU-dependent positive regulator of HH signaling |