basic FUNCTION
| induces the collapse and paralysis of neuronal growth cones |
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may be involved in regulating cell-sorting in the formation and regeneration of the periodontal attachment structure (Lallier 2004) |
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may act to repel the peripheral axons out of the spinal cord (Liu 2005) |
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classic repulsive molecule, promotes fasciculation by regulating L1CAM levels and axon-axon interactions rather than by creating a repulsive surround (Wolman 2007) |
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promotes fasciculation and modulates axon-axon interactions by regulating an adhesion molecule (Wolman 2007) |
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can function as potent anti-tumorigenic agents (but is required expression of appropriate semaphorin receptors by tumor cells) (Kigel 2008) |
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may regulate the axonal navigation of the large diameter dorsal root ganglion neurons (Takahashi 2009) |
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SEMA3D mediates the GJA1-dependent functions on cell proliferation and joint formation |
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SEMA3D functions in a common molecular pathway with GJA1 |
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SEMA3D is crucial for the normal patterning of pulmonary veins, and is a crucial pulmonary venous patterning cue |
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SEMA3E, SEMA3D direct endothelial motility through distinct molecular signaling pathways |
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might function as a tumor suppressor during the formation and development of colorctal cancer |