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FLASH GENE
Symbol PSTPIP2 contributors: mct - updated : 14-01-2015
HGNC name proline-serine-threonine phosphatase interacting protein 2
HGNC id 9581
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3054 38 334 - 1998 9804836
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines macrophage cell lines BAC1.2F5 and J774.2
fluid/secretion moderately in blood
at STAGE
physiological period fetal
Text predominantly in umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Fes/CIP4 homology domain
  • a coiled-coil domain
  • two potential SH3 binding sites
  • a proline-rich region
  • conjugated PhosphoP
    mono polymer homomer , oligo
    HOMOLOGY
    interspecies homolog to murine Pstpip2 (89.9 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    text
  • peripheral membrane protein
  • basic FUNCTION
  • major F-actin-associated protein that is tyrosine-phosphorylated in macrophages and is likely to play a role in regulating the CSF1-induced reorganization of the actin cytoskeleton
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • phosphorylated on tyrosine
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds a PEST-type protein tyrosine phosphatase
  • associates directly or indirectly with actin
  • acts as a negative feedback regulator of CSF1R signaling to suppress inflammation and osteoclastogenesis
  • assembly of FNBP1 on the plasma membranes is antagonized by PSTPIP2, another F-BAR protein implicated in auto-inflammatory disorder
  • inhibits actin polymerization by competing with FNBP1 for assembly at artificial as well as the plasma membrane
  • is a negative regulator of CASP1-autonomous IL1B production
  • assembly of FNBP1 is dependent on WAS, and its dissociation by WAS inhibition strongly induces a self-organization of PSTPIP2 at podosomes
  • is a GATA1-repressed gene that controls megakaryopoiesis
  • PSTPIP2 interacted with LYN and the expression of a dominant negative LYN (LYN DN) overwhelmed the inhibitory effect of PSTPIP2 on differentiation and ERK signaling
  • cell & other
    REGULATION
    Other phosphorylated on tyrosine
    ASSOCIATED DISORDERS
    corresponding disease(s) CRMO
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    dysregulation of PSTPIP2 due to GATA-1 deficiency may contribute to abnormal megakaryocyte proliferation and differentiation in pathogenesis of related diseases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Missense mutation (L98P) of Pstpip2 in mice leads to a disease that is phenotypically similar to Chronic recurrent multifocal osteomyelitis (CRMO) called chronic multifocal osteomyelitis (cmo)