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FLASH GENE
Symbol PNLIPRP2 contributors: mct - updated : 02-05-2011
HGNC name pancreatic lipase-related protein 2
HGNC id 9157
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1486 - 470 - 1992 1379598
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine    
Urinarybladder    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 17 amino acid hydrophobic signal peptide
  • a signal peptidase cleavage sequence G/KEV
  • a PLAT/LH2 domain
  • a lid domain
  • a N-glycosylation site
    • conjugated GlycoP
    isoforms Precursor 452 aa for the mature form
    HOMOLOGY
    interspecies ortholog to murine Plrp2
    Homologene
    FAMILY AB hydrolase superfamily, lipase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having a pancreatic triacylglycerol lipase activity
  • involved in the digestion of galactolipids, the most abundant lipids occurring in plant cells
  • can hydrolyze triolein emulsified in bile salt micelles in contrast to previous reports
  • acts preferentially on substrates forming monomers or small aggregates (micelles) dispersed in solution like monoglycerides, phospholipids and galactolipids (
  • found to express galactolipase activity, and it is assumed to be the main enzyme involved in the digestion of these common vegetable lipids in the gastrointestinal tract
  • can contribute to fat digestion during early infancy
  • may not function as a triglyceride lipase
  • unlike PNLIP, the activity of PNLIPRP2 is not restored by the addition of another pancreatic protein, colipase
  • its activity was comparable with the activity of CEL, another lipase that contributes to dietary fat digestion in newborns
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by IL4 (IL4 induces a lipase, pancreatic lipase related protein 2 (PNLIPRP2), in cytotoxic T lymphocytes (CTLs)
    inhibited by lipase inhibitor orlistat
    Other up-regulated by addition of colipase
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    W340X mutation may contribute to aberrant folding, may have other cellular effects along with the general loss of lipolytic activity, and may increase susceptibility of pancreatic exocrine cells to other metabolic stressors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Plrp2-deficient mouse pups have significant fat maldigestion that disappears coincident with the expression of Pnipl thereby confirming the important role of Plrp2 in fat digestion in the newborn mouse