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FLASH GENE
Symbol RPN2 contributors: mct/npt - updated : 09-12-2009
HGNC name ribophorin II
HGNC id 10382
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 2490 - 615 - Zmijewski (2009)
17 - 2538 - 631 - Zmijewski (2009)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrinepancreas   highly
 thyroid   highly
Reproductivefemale systemuteruscervix highly
 female systemovary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Rpn2
homolog to yeast S.cerevisiae oligosaccharyl transferase subunit SWP1
homolog to Drosophila CG6370
homolog to C.elegans M01A10.3
Homologene
FAMILY
  • ribophorin II family
  • SWP1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text type I membrane protein
    basic FUNCTION
  • catalysing the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor onto asparagine acceptor sites within an Asn-X-Ser/Thr consensus motif in newly synthesized proteins
  • required for substrate translocation and gating of the proteolytic channel (Rosenzweig 2008)
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component with RPN1 and DDOST of N-oligosacccharyl transferase
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ADRM1 (interacts with a base subunit RPN2 via its amino-terminus) (Hamazaki 2006)
  • cell & other
    REGULATION
    Other regulated by S-glutathionylation of the regulatory subunit inhibits 26 S proteasomal function (Zmijewski 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS