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FLASH GENE
Symbol NPM2 contributors: mct - updated : 10-09-2013
HGNC name nucleophosmin/nucleoplasmin, 2
HGNC id 7930
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1118 - 214 - 2003 12714744
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Skin/Tegumentskin    
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte
cell lineage
cell lines
fluid/secretion
at STAGE
IMPRINTING maternally
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a bipartite nuclear localization signal
  • a stretch of negatively charged glutamic acid and aspartic acid residues, involved in protamine and histone binding
  • several putative ser and thr phosphorylation sites
  • a large acidic tract in its C-terminal tail (Npm2-A2) able to bind histones and form large complexes
  • HOMOLOGY
    interspecies ortholog to rattus npm2
    ortholog to Xenopus nucleoplasmin (Np), a chaperone that binds histonesNpm2
    Homologene
    FAMILY nucleoplasmin family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text
  • nuclear localization before nuclear membrane breakdown, then redistributed to the cytoplasm
  • expression limited to growing oocyte
  • basic FUNCTION
  • may be involved in sperm DNA decondensation during fertilization
  • involved in sperm chromatin remodeling in mammals
  • NPM1 and NPM2 mediated nucleosome assembly independently of other NPM proteins
  • maximal sperm chromatin remodeling activity of NPM2 required the inhibition of its non-specific nucleic acid-binding activity by phosphorylation
  • the NPM proteins (NPM1, NPM2, NPM3) cooperatively regulate chromatin disassembly and assembly in the early embryo and in somatic cells
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA DNA binding
    RNA
    small molecule
    protein
  • histone binding
  • NPM2 targeting of NLBs (Nucleolus-like bodies) is regulated by the K-rich motif and is essential for the formation of NLBs
  • beyond their important role in the remodeling of paternal chromatin in the early stages of embryogenesis, NPM2 and NPM3 and NASP members can interact with a plethora of proteins in addition to histones in somatic cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • female Npm2 null mice showed defects in preimplantation embryo development, with abnormalities in oocyte and early embryonic nuclei
  • in male mice, sperm DNA decondensation proceeded in the absence of Npm2