basic FUNCTION
| may protect cells and enzymes from oxidative dammage by catalyzing the reduction of hydrogen perodie, lipid peroxides and organic peroxides |
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may act to protect sperm form premature acrosome reaction in the epididymis |
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because of the very low level of expression of the active form, these functions remains to be demonstrated |
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key importance of GPX5 as an extracellular antioxidant designed to protect maturing mammalian spermatozoa from oxidative stress |
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GPX5 protein, and the epithelial proteins GPX1, GPX3, and cellular GPX4, all functioning in the mammalian epididymis at different stages of the sperm epididymal journey, and in different epididymis compartments |