Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GPX5 contributors: mct - updated : 12-09-2016
HGNC name glutathione peroxidase 5 (epididymal androgen-related protein)
HGNC id 4557
RNA
TRANSCRIPTS type messenger
text multiple alternatively spliced variants but only one encoding an active glutathione peroxidase
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 splicing 1452 25 221 epididymis-specific 1998 9639555
includes exons 1 to 5 and encodes the active form enzyme
4 splicing 1334 - 100 - 1998 9639555
lacking exon 3 and encoding an inactive enzyme
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemmale genital tractepididymis   Homo sapiens
 male systemmale genital tract    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Gpx5
Homologene
FAMILY glutathione peroxidase family
CATEGORY chaperone/stress , enzyme
SUBCELLULAR LOCALIZATION extracellular
text secreted
basic FUNCTION
  • may protect cells and enzymes from oxidative dammage by catalyzing the reduction of hydrogen perodie, lipid peroxides and organic peroxides
  • may act to protect sperm form premature acrosome reaction in the epididymis
  • because of the very low level of expression of the active form, these functions remains to be demonstrated
  • key importance of GPX5 as an extracellular antioxidant designed to protect maturing mammalian spermatozoa from oxidative stress
  • GPX5 protein, and the epithelial proteins GPX1, GPX3, and cellular GPX4, all functioning in the mammalian epididymis at different stages of the sperm epididymal journey, and in different epididymis compartments
  • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with NME5 (NME5 expression plays a critical role in spermiogenesis by increasing the cellular levels of GPX5 to eliminate reactive oxygen species)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • spermatozoa of mice lacking both the sperm nucleus glutathione peroxidase 4 (snGPx4) and the epididymal glutathione peroxidase 5 (GPx5) activities display sperm nucleus structural abnormalities including delayed and defective nuclear compaction, nuclear instability and DNA damage