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FLASH GENE
Symbol SLC39A6 contributors: - updated : 31-01-2006
HGNC name solute carrier family 39 (zinc transporter), member 6
HGNC id 18607
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3637 - 755 - -
8 - 1681 - 433 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrine    
Hearing/Equilibriumearinnercochlea  
Nervousbrainbasal nucleicorpus callosum  
 brainhindbraincerebellum  
 braindiencephalonhypothalamus  
Reproductivefemale systemplacenta   
 female systembreast   
 male systemtestis   
 male systemprostate   
Urinarykidney    
cell lineage
cell lines HeLa and lung carcinoma
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential metalloprotease motif (HEX P H E XGD), which fits the consensus sequence for the catalytic zinc-binding site motif of the zincin metalloproteases
  • two histidine-rich sequences
  • a HELP domain
  • HOMOLOGY
    interspecies ortholog to murine Slc39a6
    homolog to dog liv-1
    ortholog to rattus Slc39a6_predicted
    Homologene
    FAMILY
  • ZIP transporter (tc 2.a.5) family
  • KE4/catsup subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • would be involved in heavy metal ion transport
  • may be a suitable prognostic marker for lymph-node involvement and a key determinant of metastatic spread in steroid hormone receptor-positive disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text may be a zinc transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    induced by oestrogen treatment
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oestrogen-positive breast cancer with metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS